Absence of a natural inhibitor of the tRNA methylases from fetal and tumor tissues.

نویسنده

  • S J Kerr
چکیده

The inhibitor of tRNA methylases of normal adult tissues has been resolved into two fractions, a high molecular weight protein and a low molecular weight (<700) component. The high molecular weight component is absent from embryonic and tumor tissues, both of which are known to possess high tRNA methylase capacity.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Transfer RNA methylase activity in normal monkey liver and in carcinogen-induced hepatoma.

Hepatomas were induced in monkeys by the administration of jV-nitrosodiethylamine. An a-fetoprotein, not normally found in adult monkeys, was present in the serum of the majority of the animals with the liver tumor. Frequently, the test for serum a-fetoprotein was positive prior to any histolÃ3gica!evidence of a cancer. With tRNA from Escherichia coli K12W6 or from normal adult monkey liver or ...

متن کامل

Transfer RNA Methylases of Normal Cells, Virus-transformed Cells, and Tumors Derived from Transformed Cells1

Transfer RNA methylases (rate and capacity) were studied in normal cells and tissues, in RNA and DNA oncogenic virus-transformed cells, and in tumors derived from the transformed cells. The DNA oncogenic virus-transformed cells (SV40 and polyoma) contained greater tRNA methylase capacities than their nontransformed normal cells. In contrast, no difference was observed (capacity or rate) between...

متن کامل

Transfer RNA methylases of normal cells, virus-transformed cells, and tumors derived from transformed cells.

Transfer RNA methylases (rate and capacity) were studied in normal cells and tissues, in RNA and DNA oncogenic virus-transformed cells, and in tumors derived from the transformed cells. The DNA oncogenic virus-transformed cells (SV40 and polyoma) contained greater tRNA methylase capacities than their nontransformed normal cells. In contrast, no difference was observed (capacity or rate) between...

متن کامل

Detection of Survivin Gene Expression in Formalin-Fixed Paraffin-Embedded Tissues of Human Osteosarcoma: Its Potential Usefulness in Diagnosis and Prognosis of Bone Tumors

Osteosarcoma is a relatively uncommon malignancy however, it is the most common form of primary malignant bone tumors in human. Diagnosis and prognosis of patients with osteosarcoma is limited to clinico-radiopathological parameters, whereas molecular markers of tumor aggression have been poorly identified. Survivin, an inhibitor of apoptosis (IAP), is unique for its expression in human tumors ...

متن کامل

Prohibitin 2 mRNA downregulation in breast cancer tumor tissues

Introduction: Breast cancer is the most important cause of cancer mortality among women, therefore the study of its causative or aggravating factors seems necessary. In this study, the mRNA levels of the PHB2 gene were evaluated in tumor and adjacent non-tumor tissues of 50 women diagnosed with invasive ductal carcinoma of the breast. Methods: RNX-Plus solution was used to isolate total RNA fro...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 68 2  شماره 

صفحات  -

تاریخ انتشار 1971